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KMID : 0372919930140010017
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Journal of Biomedical Engineering Research
1993 Volume.14 No. 1 p.17 ~ p.22
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Temperature Rise During Laser Photodynamic Therapy in a Mouse Tumor Model
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Yoon Gilwon
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Abstract
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Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided intro two groups. One group was injected with Photofrin H , intravenously (2.5mg/kg body weights) . The other group received no Photofrin E Mice from both groups were irradiated for ap- proximately 15 minutes at 100,300, or 500 mW/cm with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photofrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cml irradiation exceeded values for hyperthermia. Lights and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise.
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KEYWORD
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